This might be related to the fact that hypertriglyceridemia stimulates the activity of cholesteryl ester transfer protein, which exchanges triglycerides from triglyceride‐rich lipoproteins for cholesteryl esters from high‐ and LDLs24; triglycerides enrichment of high‐ and LDLs particles renders them better substrates for lipolysis by hepatic lipase, resulting in HDL catabolism and elimination and the formation of more numerous, denser LDLs particles. This evidence concerns the gene LIPC and hypertriglyceridemia.