Survival time of tumor-bearing mice was shorter in LN229- and U118MG-TRIM22-FL groups (LN229: 26 vs. 39 days, TRIM22-FL vs. EV, respectively, P < 0.05; U118MG: 27 vs. 34 days, TRIM22-FL vs. EV, respectively, P < 0.05; Fig. 3f), but remained stable in LN229- and U118MG-TRIM22-ΔRING (LN229: 39 vs. 39 days, TRIM22-ΔRING vs. EV, respectively, P = n.s.; U118MG: 35 vs. 34 days, TRIM22-ΔRING vs. EV, respectively, P = n.s.; Fig. 3f) relative to EV groups. Here, FLT3LG is linked to neoplasm.