In addition, a combination of adenoviral-mediated PTEN and PI3K inhibitor inhibits the malignant growth of glioblastoma cells.49 In our study, knockdown of E2F7 increased the expression of PTEN by decreasing the recruitment of EZH2 and H3K27me3 to the promoter of PTEN in glioblastoma cells. The gene discussed is PTEN; the disease is glioblastoma.