E2F transcription factors are considered to be important drivers of tumour growth, which are involved in various progressions such as cell cycle, angiogenesis and DNA-damage response.6–9 E2Fs are classified as typical E2Fs, including E2F1−E2F6 and atypical E2Fs (E2F7 and E2F8).10 Typical E2Fs contain a conserved DBD domain (DNA binding) and a DIM domain (protein binding). The gene discussed is E2F7; the disease is neoplasm.