GSEA analysis by using the ccRCC gene pool from TCGA database indicated that genes upregulated by high YB1 and EphA2 expression were enriched in the multiple-drug-resistance pathway, and genes upregulated by high EphA2 expression were enriched in renal cell-carcinoma pathway (Fig. 6a). Here, EPHA2 is linked to hereditary clear cell renal cell carcinoma.