Western blot analysis of tumor tissue lysates showed that ALW reduced the phosphorylation levels of EphA2, STAT3, AKT, and ERK (Fig. 9f), consistent with the results observed in vitro (Fig. 7g, h) and the results of stable knockdown of EphA2 observed in vivo (Fig. 8f). The gene discussed is AKT1; the disease is neoplasm.