Currently, limited therapeutic options are available in the clinic to treat MC-driven disorders.2 Most MC-stabilizing drugs and H1 antagonists have minimal activity against MCs, and many patients become refractory over time, underscoring the importance for new therapeutics.2 Anti-IgE monoclonal antibodies, e.g. omalizumab, have been shown to be effective in some allergic diseases, including chronic urticaria, eosinophilic asthma, and nasal polyposis. This evidence concerns the gene IGHE and Nasal polyposis.