TCF7L2 and type 2 diabetes mellitus: Our enrichment analysis carried out on the comprehensive set of 212 T2D-associated risk SNPs revealed that the highest number of significantly enriched risk alleles belonged to TCF7L2 almost in all populations except for the EAS, where this gene harbors the maximum number of significantly depleted risk alleles across populations; several depleted TCF7L2 risk alleles have also been identified in AFR, AMR, and SAS populations, but only three risk alleles in IR and no risk allele of this gene in EUR populations were depleted.