The unsupervised heat map analysis showed that Nrf2 target genes SOD2, SLC3A1, AKRC1, GCLC, HO-1, NQO1, and SOD1 were highly upregulated in the cisplatin-resistant tumor cells compared to the cisplatin sensitive tumor counterparts (Fig. 3a), suggesting that cisplatin treatment potentially plays a significant role in Nrf2 pathway activation. This evidence concerns the gene HMOX1 and neoplasm.