RAC1 and renal cell carcinoma: We further observed a decrease in Rac1, a small GTPase, and a reduction in the phosphorylation of paxillin, a focal adhesion protein, at mRNA levels (Figs. S3, S5) and protein levels (Figs. 6g, I–j, S8C–F) in both miR-141 overexpressed and CDKN2B-AS1 inhibited RCC cell lines which in turn are involved in regulating cellular migration/invasion.