Recently, Mehdawi et al. reported that the activation of LTC4-induced CysLT2R signalling led to the activation of 15-PGDH, which further promoted the differentiation of colon cancer cells in a 15-PGDH-dependent manner, as evidenced by the upregulation of intestinal differentiation markers20. The gene discussed is HPGD; the disease is malignant colon neoplasm.