LGR5 and colonic neoplasm: The mRNA expression levels of the colon cancer-specific stemness markers DCLK1, LGR5, and ALDH1A1 were elevated in HT-29 as well as in Caco-2 cell-derived colonospheres and were downregulated after LTC4 stimulation (Fig. 6i; Supplementary Fig. S9A–H).