PITX2 and atrial fibrillation: Multivariate analysis considering 4 clinical parameters shown to predict recurrent AF after ablation (21) and PITX2 concentration with a forward selection process selected PITX2 as the variable most strongly associated with AF recurrence (OR 0.840, 95% CI 0.695, 1.014), whereby every 2–(ΔΔCt) increase in PITX2 expression levels reduced the odds of recurrent AF by 16%.