Contrary to the iba1-ir results, the TMEM119-ir parameters did not correlate to brain weight (Supplemental Figures 11 and 12), which suggests that only infiltrating macrophages may be linked to brain atrophy, which seems consistent with the previously mentioned association between brain weight and lack of IGF1 in CD11c macrophages and/or microglia (24). This evidence concerns the gene TMEM119 and Brain atrophy.