For example, Kcnn4, Kcnq1, Kcne3, or Kcnk5 silencing does not produce obstructions or CF-like phenotypes in the intestine of the animals, as expected from genes coding for K+ channels with tested roles in epithelial anion secretion (26, 28, 35, 36). This evidence concerns the gene KCNK5 and cystic fibrosis.