While Ptgs2 and Ptges mRNA, which encode COX-2 and PTGS2, were induced by hyperglycemia, other enzymes that metabolize arachidonic acid (5-LO, 15-LO, or thromboxane A synthetase 1) were not in the M1-MΦ. The gene discussed is PTGS2; the disease is Hyperglycemia.