The rs762551 (CYP1A2*1F; −163C > A) polymorphism in intron 1 of CYP1A2 at position 734 downstream of the first transcribed nucleotide was reported to associate with caffeine intake in different genders and ethnicities [32, 33], and to play a role in lipid metabolism thereby indicating a participation in age-related macular degeneration [34]. Here, CYP1A2 is linked to age-related macular degeneration.