Further, mouse CES1G—a protein expressed by one of a cluster of eight syntenic genes (Ces1a through Ces1h) orthologous to the human CES1 gene—has been shown to have triglyceride hydrolase activity as Ces1g null mice display hyperlipidemia and abnormal lipid homeostasis including increased liver and circulating cholesterol and triglycerides, and altered saturated and unsaturated fatty acid levels [77, 78]. The gene discussed is PNPLA2; the disease is hyperlipidemia.