A clinical trial of 72 systemic lupus erythematosus (SLE) patients and 63 HCs showed that serum IL-36α and IL-36γ levels were increased in SLE patients and related to systemic lupus erythematosus disease activity index (SLEDAI) scores, which suggest that IL-36 is associated with SLE disease activity [14, 15]. Here, IL36G is linked to systemic lupus erythematosus.