As a result, LPCAT1, PLA2G1B, and SMPD4 were significantly overexpressed in the experimental group (HCC tissues) compared with the control group (para‐carcinoma tissues) (P < .001) (Figure 14A‐C), while the expression of LCAT and ACSL6 were significantly lower in the experimental group (HCC tissues) compared with the control group (para‐carcinoma tissues) (P < .001) (Figure 14D‐E), which is consistent with our bioinformatics analysis. The gene discussed is SMPD4; the disease is hepatocellular carcinoma.