In the present work, we carried out complicated bioinformatic analyses to successfully identify five lipid metabolism‐related genes that were associated with HCC prognosis, including ACSL6, LPCAT1, PLA2G1B, LCAT, and SMPD4. To begin with, we first investigated those heterogeneities in lipid metabolism‐related gene expression patterns in HCC tissue samples compared with noncarcinoma tissue samples, and subsequently identified prognosis‐related genes. Here, SMPD4 is linked to hepatocellular carcinoma.