As a result, a lipid metabolism‐related signature consisting of acyl‐CoA synthetase long‐chain family member 6 (ACSL6), lysophosphatidylcholine acyltransferase 1, phospholipase A2 group 1B, lecithin‐cholesterol acyltransferase (LCAT), and sphingomyelin phosphodiesterase 4 (SMPD4) was identified among HCC patients. This evidence concerns the gene SMPD4 and hepatocellular carcinoma.