Five metabolic genes, acyl‐CoA synthetase long‐chain family member 6 (ACSL6), phospholipase A2 group 1B (PLA2G1B), sphingomyelin phosphodiesterase 4 (SMPD4), lysophosphatidylcholine acyltransferase 1 (LPCAT1), and lecithin‐cholesterol acyltransferase (LCAT), were subsequently selected from the 36 OS‐related genes via LASSO and multivariate Cox regression analyses to establish a prognostic model, aiming to categorize HCC patients into two groups with discrete OS, namely, the high‐ and low‐risk groups (Table 1). This evidence concerns the gene ACSL6 and hepatocellular carcinoma.