CYP2C9 and digestive system disorder: Although studies indicate that the use of this drug is common and generally well tolerated in the clinic, a research(38) has already reported that the presence of genetic variants of the CYP2C9 enzyme, more specifically the CYP2C9 * 2 and CYP2C9 * 3 allele, considerably increases the risk of gastrointestinal disorders, including bleeding, during the use of NSAID other than Aspirin.