BRCA1 and hyperinsulinemic hypoglycemia, familial, 4: Other potential combination partners for PARPi are inhibitors of cyclin dependent kinases (CDKs).[142, 143] In addition to playing a crucial role in cell‐cycle regulation, CDK1 was found to phosphorylate BRCA1, an event essential for efficient BRCA1 focus formation and HR repair.[144] Therefore, CDK inhibition presents a method to induce a form of BRCA‐deficiency, thereby rendering treated cells sensitive to PARPi.