PARP1 and cancer: The activity of PARP in DNA repair has been shown to counteract many types of DNA damaging chemotherapies and thus is crucial for the emergence of resistance during prolonged cancer treatment.[22] Interestingly, overexpression of PARP has been noted in several cancer cell lines compared to their normal counterparts.[97] The role of PARP hyperactivation in therapeutic resistance to cisplatin in the majority of advanced tumours and human cisplatin‐resistant cancer cells has been described in detail by Michels et al.