The up‐regulation of CXCL1‐CXCR2 plays a critical role in mediating monocyte infiltration, pro‐inflammatory responses and oxidative stress, by stimulating a variety of cell signalling pathways, including NF‐κB, AKT/mTOR, ERK1/2, STAT3, NADPH oxidase and TGF‐β1/Smad2/3 thereby leading to hypertension and cardiac remodelling in different animal models.12, 13, 14. Here, SMAD2 is linked to hypertensive disorder.