RIGI and melanoma: In contrast, the expression of RNA helicase RIG‐I (also known as DDX58) and MDA‐5 (melanoma differentiation‐associated gene 5, also known as interferon induced with helicase C domain 1 or IFIH1) (Estornes et al, 2013), which recognize short and long cytoplasmic dsRNAs, respectively, was significantly increased at the RNA level (Fig 5B).