In 44 of these eyes a pink-orange subretinal nodular lesion on fundoscopy, and/or a peaked/dome-shaped elevation of the RPE, usually with a hyperreflective subretinal accumulation beneath it, was found at baseline, whereas in 30 eyes a macular neovascularization without evidence of another diagnosis than AMD that either did not respond or only partially responded to previous anti-VEGF treatment was seen. The gene discussed is VEGFA; the disease is age-related macular degeneration.