As for the key genes associated with PHY906-CPT11 treatment, we found that EIF4E, PRR15, ANXA2, PRSS12, HNRNPA3, PFDN2, RGS10, GNG11, and TMSB4X showed obviously different expression levels between normal and tumor samples in colon cancer (Supplementary Figures S3 and S4). Here, PFDN2 is linked to colonic neoplasm.