Thus, we speculated that PHY906-CPT11 exerts therapeutic role in colon cancer by regulating the expression of GBP2, EIF4E, PRR15, ANXA2, HNRNPA3, NCF1, C3AR1, PFDN2, RGS10, GNG11, and TMSB4X. The gene discussed is ANXA2; the disease is malignant colon neoplasm.