After filtering for GS and MM value, we eventually obtained 36 hub genes (Loc100041932, 1300001i01rik, Kdelr2, Lasp1, 1110005a03rik, Llgl2, Copa, Orai1, Bcar1, Actn4, Col4a2, Jmjd5, Arrb1, Cry2, Gtf2b, Tmem64, Zfp319, Myadm, Sparc, Ehmt1, Ctgf, Litaf, Psmc6, Sms, Ckmt1, Oat, Zyx, Col18a1, Cox17, Enpp5, Prickle1, Pck2, Slc44a4, Ppap2b, Fn1, and Tpp1) and their expression were significant in distinguishing PHY906-CPT11 and other treatments for colon cancers. Here, ENPP5 is linked to malignant colon neoplasm.