IRS1 and cancer: Then, we obtained 35 hub genes within the pink module, and there were 23 cancer-related genes (Lsm4, Arpp19, Rtp4, Ifitm3, Flywch1, Ppia, Bre, Psmb8, Ank2, Mrpl3, Hey1, Impa2, Emp2, Irs1, Psmb9, Epsti1, Ccl5, Bloc1s1, Gbp2, Adam10, Adi1, Aif1l, and Dusp1), which functioned in tumorigenesis and prognosis.