Thus, we speculated that PHY906-CPT11 exerts therapeutic role in colon cancer by regulating the expression of GBP2, EIF4E, PRR15, ANXA2, HNRNPA3, NCF1, C3AR1, PFDN2, RGS10, GNG11, and TMSB4X. Here, RGS10 is linked to colonic neoplasm.