Although the concentration of CDCA and CA (both high potency and low potency FXR agonists) increased in HFD-fed mice on day 10 after infection, the proportion of this increase was not as large and it ranged from 2–13-fold, compared to RD-fed mice (Fig. 6d and Supplementary Fig. 4a). The gene discussed is NR1H4; the disease is infection.