NR1H4 and clostridium difficile infection: Although the role of FXR signaling in CDI pathogenesis is not completely understood, diarrhea resolution in patients with recurrent CDI was associated with activation of FXR signaling pathways.39 We observed that 10 days of OCA treatment-induced FXR signaling molecules and reduced hepatic BA synthesis in RD-fed mice as well, but this change did not affect overall CDI severity in this group.