Because MCLMR and FEVR patients are reported to have a mutation in only one allele of KIF11, we next created two heterozygous CRISPR/Cas9 clonal lines of RPE1 cells to experimentally represent this genetic state (crKIF11-1 and crKIF11-2). The gene discussed is KIF11; the disease is microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability.