ANGPT2 and Abnormal renal physiology: In this study, our main findings were (1) decreased levels of miR-34a, -224 and -452 in diabetes patients with LVDD and in female diabetes patients with an eGFR < 60 ml/min but increased plasma miR-224 and miR-452 in diabetic women with HFpEF versus diabetic men with HFpEF; (2) regression analysis demonstrated that sex, DM and renal dysfunction are associated with plasma miR-34a levels in patients with LVDD; and (3) Increased levels of plasma Ang-2 in diabetic women with HFpEF but not in diabetic men with HFpEF.