Histopathological analysis revealed that, whereas femurs from control mice transplanted with FLT3 ITD+ AML cells (from case #2) were packed with hCD45+ cells with numerous hCD34+ cells, those from CPZ-treated mice showed recovery of normal hematopoiesis with a small number of hCD45+ cells and rare hCD34+ cells. Here, FLT3 is linked to acute myeloid leukemia.