Steady state TA of C57/Bl6 mice were compared to snake venom-derived cardiotoxin (CTX) injected C57/Bl6 mice, to Sarcoglycan-β null (β-SGnull, animal model with C57/Bl6 background resembling LGMD type 2E) mice and to mdx thus to characterize the presence of MICAL2 during acute and chronic degeneration/regeneration processes, respectively. This evidence concerns the gene MICAL2 and autosomal recessive limb-girdle muscular dystrophy type 2E.