Aldoa catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate and is critically involved in glycogen storage: deficiency of this enzyme causes Glycogen Storage Disease XII leading to excessive liver accumulation of glycogen38. The gene discussed is ALDOA; the disease is glycogen storage disease due to aldolase A deficiency.