In addition, as shown in Supplementary Fig. 3A, C, the western blotting and IHC results showed that DNER impacted the tumour growth in vivo was related to the level of Ki67, which is consistent with the positive correlation between DNER expression and ki67 expression in BC patients of TCGA database (Supplementary Fig. 3B). Here, MKI67 is linked to neoplasm.