In this study, we found that NE significantly increased the phosphorylation of various kinase’s residues, including AKT-Ser473/Thr308, GSK-3α/β-Ser9/21, p27-Thr198, p70S6K-Thr389, PRAS40-Thr246, etc. Furthermore, we found that NE-induced β-catenin expression and migration/invasion of ovarian cancer cells could be reversed by the AKT inhibitor in vitro. Here, RPS6KB1 is linked to ovarian cancer.