In addition, we conducted the wound-healing assays (Supplementary Fig. 1) and the 3D tumor spheroid invasion assays (Supplementary Fig. 2) to evaluate the effects of NE/AKT/β-catenin signaling transduction and MLT on the motility of EOC cells in vitro at 48 h, which were consistent with the results of transwell assays. The gene discussed is AKT1; the disease is neoplasm.