SNAI2 and cancer: Many studies demonstrated that catecholamine hormones induced EMT and promoted metastatic capacity in various kinds of cancer, including pancreatic cancer11, gastric cancer12, ovarian cancer7, etc. EMT is complexly orchestrated by numerous EMT-inducing transcription factors, such as SNAIL, SLUG, TWIST, β-catenin, etc. Choi et al.7 reported that NE facilitated ovarian cancer aggressiveness through hTERT-mediated SLUG expression.