In the same study, downregulation of choline acetyltransferase activitywas observed in the temporal and parietal cortices, particularly in thoseexperiencing hallucinations.79Treatment with the cholinesterase inhibitor rivastigmine decreased delusions andhallucinations in patients with DLB compared to placebo.95 The mechanism underlying theefficacy of cholinesterase inhibition in the treatment of DLB remainsunresolved. The gene discussed is CHAT; the disease is Lewy body dementia.