Aberrant aggregated proteins in AD produce β-amyloid plaquesand neurofibrillary tangles (hyperphosphorylated tau aggregates).39,40 In DLB and PD dementia, Lewy bodies and Lewy neurites,composed primarily of phosphorylated α-synuclein aggregates, accumulatepreferentially in limbic brain regions.41–43 FTD may beassociated with either aggregated tau protein or aggregated trans-activatorregulatory DNA-binding 43 (TDP-43) protein.44 The gene discussed is MAPT; the disease is Alzheimer disease.