Despite the progress in understanding ASPH involvement in signaling pathways, the high number of other potential targets of ASPH hydroxylation suggests that the ASPH impact on tumor biology might be more complex, including potential impact on the transforming growth factor beta (TGF-β), growth arrest specific 6/AXL receptor tyrosine kinase (Gas6/Axl), and Wnt pathways. The gene discussed is ASPH; the disease is neoplasm.