MATR3 and amyotrophic lateral sclerosis: To investigate the role of MATR3 in an in vivo model system, we generated transgenic Drosophila lines with site-specific integration of either wild type (WT) human MATR3 or MATR3 with ALS-associated mutations Ser85Cys (S85C) and Phe115Cys (F115C) with an N-terminal FLAG tag.