RT-qPCR for rationally-selected targets from the shared transcriptome, particularly those that show high binding affinity to both MATR3 and hnRNPM, and additionally, have been previously associated to neurodegeneration in ALS including DYRK1A, SMYD3 and ZNF644, revealed that F115C and S85C mutants exhibit significantly higher binding to these transcripts compared to WT (Fig. 8b–d). Here, DYRK1A is linked to amyotrophic lateral sclerosis.