For example, a hepatocellular carcinoma (HCC) SB screen in a chronic hepatitis B autochthonous model yielded 21 truncal drivers compared with 2860 candidate late-stage drivers; 1199 genes were related to hepatocellular metabolism, including truncal drivers such as Pten, Adk, and Zbtb20, suggesting a prominent role for aberrant metabolism in HCC [117]. This evidence concerns the gene ADK and hepatocellular carcinoma.