Furthermore, sera from sporadic ALS patients were found to contain IgM antibodies reacting with misfolded SOD1 (recombinant SOD1 oxidized with 10 mM H2O2), and the sporadic ALS cases with higher levels of the IgM antibodies (n = 153) exhibited a longer survival of 6.4 years than the subjects lacking those antibodies (n = 127) [119]. Here, CD40LG is linked to amyotrophic lateral sclerosis.