SOD1 and amyotrophic lateral sclerosis: To test if SOD1 becomes misfolded in CSF of ALS, CSF samples from 96 ALS cases (57 sporadic ALS, 22 SOD1-ALS, 17 Non-SOD1 familial ALS) and 38 neurological controls were examined with sandwich ELISA using misfolded-SOD1 antibodies (Ra 24–39, Ra 57–72, and Ra 111–127) [94].