SOD1 and amyotrophic lateral sclerosis: Therefore, clearance of misfolded SOD1 by utilizing the immune system would be a potential treatment for patients with sporadic as well as familial ALS; nonetheless, it should be also noted that, in sera of sporadic ALS subjects, higher levels of IgG antibodies reacting with normal wild-type SOD1 associated with a shorter survival of 4.1 years [119].