More precisely, sandwich ELISA was performed on CSF from 21 ALS cases (20 sporadic ALS, 1 SOD1-ALS) and 40 controls by using misfolded-SOD1 antibodies (C4F6, UβB, EDI, apoSOD, 24–39 and SOD1int). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.