Significantly more amounts of SOD1 were also detected in the 1% Nonidet P-40-insoluble pellets from two sporadic ALS cases (a non-SOD1 ALS and a case with C9orf72 mutation) as well as two SOD1-ALS cases (A4V and G72C mutations) than those of three Alzheimer’s disease cases and four non-neurological controls [61]. This evidence concerns the gene SOD1 and early-onset autosomal dominant Alzheimer disease.