We demonstrated a dose-dependent increase in UPR protein GRP78 (BiP) levels in LS174T cells when exposed to increasing doses of celecoxib (0–100 μM) or orlistat (0–100 μM) for 24–48 h, consistent with their known role as ERS aggravators (Fig. 2a). Here, HSPA5 is linked to amelogenesis imperfecta type 1G.