According to the 2017 World Health Organization (WHO) digestive neuroendocrine tumor classification, neuroendocrine neoplasm (NEN) can be divided into three categories based on Ki-67 levels and mitotic counts (× 10 HPF): Grade 1 (G1, Ki67 ≤ 2%, mitoses< 2), Grade 2 (G2, 3% < Ki67 ≤ 20%, 2 ≤ mitoses≤20), Grade 3 (G3, Ki67 > 20%, mitoses> 20) [8]. The gene discussed is MKI67; the disease is neuroendocrine neoplasm.