In addition to TNF-α, other humoral agents associated with obesity might also be contributing to the activation of WNT signaling like IL-1β and adiponectin, which is decreased in the obese state and is not an inflammatory cytokine that can modulate GSK3β/β-Catenin signaling pathway [38]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.