As for natriuretic peptides, numerous cross‐sectional studies have shown that plasma BNP concentrations are increased in patients with HCM and related to symptoms of heart failure, exercise capacity, severity of hypertrophy, LVOT obstruction, LV systolic and diastolic dysfunctions, left atrial diameter, LV mass index, and LGE(+) detected by CMR.19, 27, 28, 29, 30, 31, 32, 33, 34. Here, NPPB is linked to hypertrophy.