As sunitinib also has been shown to inhibit TNIK kinase activity [21], and to address the relevance between TNIK inhibition and TGF-β1-induced EMT, we evaluated the effect of sunitinib as an anti-cancer agent inhibiting TNIK kinase activity and the EMT in NSCLC cells. The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.