DPT and infection: In this work, via screening the fly strains from the Bloomington Drosophila library, we found Gal80ts-UAS-dmyc flies significantly decrease the expressions of Dpt, Drosocin, Attacin and Cecropin A1 after infection with gram-negative bacteria Escherichia coli (E. coli), indicating dMyc regulates the Imd pathway (S1 Fig).