FOXP3 and preeclampsia: The only publications that we know of investigating FOXP3 expression in actual human placental bed biopsies demonstrated that the percentage of FOXP3+ T cells was significantly decreased in patients with preeclampsia, and FOXP3 mRNA expression was reduced in endometrial biopsies of infertile women, highlighting the importance of functional Tregs for a healthy pregnancy (57, 113).