Thus, because of the prothrombotic role of the cytokine storm and of the probable complement cascade hyperactivation, humanized monoclonal antibodies (hMAbs) that target and inhibit these pathways are being used in COVID-19 clinical trials: Tocilizumab (hMAb that targets IL-6 receptor) and Eculizumab (hMAb that targets complement component 5 protein-C5). Here, C5 is linked to COVID-19.