The expression of YTHDF2 is up‐regulated in hepatocellular carcinoma, pancreatic cancer, etc,55, 58, 59 the expression of YTHDF1 is up‐regulated in colorectal cancer, hepatocellular carcinoma, ovarian cancer, lung cancer, etc,60, 61, 62, 63 and both YTHDF1 and YTHDF2 are independent risk factors for OS. The gene discussed is YTHDF1; the disease is colorectal cancer.