In contrast, both m6A methyltransferases (METTL3 and METTL14) and m6A demethylases (FTO) act as tumour suppressor genes in renal cell carcinoma, indicating that the recruited m6A‐binding protein and potential downstream target play important roles in tumour development. This evidence concerns the gene METTL14 and hereditary clear cell renal cell carcinoma.