The expression of YTHDF2 is up‐regulated in hepatocellular carcinoma, pancreatic cancer, etc,55, 58, 59 the expression of YTHDF1 is up‐regulated in colorectal cancer, hepatocellular carcinoma, ovarian cancer, lung cancer, etc,60, 61, 62, 63 and both YTHDF1 and YTHDF2 are independent risk factors for OS. This evidence concerns the gene YTHDF2 and colorectal cancer.