Cheng et al31 found that the expression of METTL3 was elevated in bladder cancer and further identified AF4/FMR2 family member 4 (AFF4), key regulators of the NF‐κB pathway (IKBKB and RELA) and MYC as direct downstream targets of METTL3. This evidence concerns the gene AFF4 and urinary bladder cancer.