After administration of the vaccine, there was a boost in IL‐10 and transforming growth factor β (TGF‐β) concentrations, immunomodulatory cytokines that ameliorate experimental arthritis, and a decrease in interferon γ (IFN‐γ) secreted by effector T cells by a shift in type 2/3T helper cell (Th2/3).80 This evidence concerns the gene TGFB1 and arthritic joint disease.