In a cohort of patients with synchronous or metachronous liver metastases from colorectal adenocarcinoma (Supplementary Table 1), we examined the expression of 48 genes in the hPlk4 interactome as defined by mass spectrometry19 plus 10 additional related genes including FAM46C (Supplementary Table 2), in banked paired samples of primary tumor (T) and adjacent normal mucosa (NM), microdissected to isolate cancer cells and intestinal mucosal cells, respectively. This evidence concerns the gene TENT5C and cancer.