It can be speculated that TMPRSS13-mediated ENaC activation in CRC (ENaC is expressed in colon epithelial cells and datasets in OncomineTM report high expression of ENaC in both DLD1 and HCT116 cells68,69) could contribute to survival and invasion, whereas silencing of the protease may decrease ENaC activation, leading to increased apoptosis and enhanced sensitivity to HA14-1 and paclitaxel. The gene discussed is TMPRSS13; the disease is colorectal carcinoma.