Moreover, our study demonstrated that knockdown of FXR in colon cancer cells induced EMT, accompanied by upregulation of Snail, Slug, vimentin, fibronectin, and MMP-9, and downregulation of E-cadherin and ZO-1, whereas ectopic expression of FXR had reversed change. This evidence concerns the gene NR1H4 and malignant colon neoplasm.