Glucocorticoid receptor (GR) could inhibit tumor proliferation by repressing cyclin D1 expression via targeting of the β-catenin/TCF complex56 (theme II); and β-catenin acts as a coactivator of androgen receptor (AR) transcription and promotes cell proliferation and prostate pathogenesis57 (theme I). The gene discussed is CCND1; the disease is neoplasm.