Both H&E and Ki67 staining performed on lung sections from mice that either received nanoplex–siMK2, nanoplex–siXPA, or the nanoplex–siMK2/siXPA combination with cisplatin further confirmed reductions in tumor burden and proliferation (Fig. 4e), consistent with the results of whole animal bioluminescence imaging (Fig. 4c, d). This evidence concerns the gene MKI67 and neoplasm.